COS-7-based model: methodological approach to study John Cunningham virus replication cycle
نویسندگان
چکیده
منابع مشابه
John Cunningham virus T-antigen expression in anal carcinoma.
BACKGROUND Anal carcinoma is thought to be driven by human papillomavirus (HPV) infection through interrupting function of cell regulatory proteins such as p53 and pRb. John Cunningham virus (JCV) expresses a T-antigen that causes malignant transformation through development of aneuploidy and interaction with some of the same regulatory proteins as HPV. JCV T-antigen is present in brain, gastri...
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BACKGROUND John Cunningham virus (JCV) constitutes a family of polyoma viruses, which plays important roles in the progressive multifocal leukoencephalopathy (PML) and tumorigenesis. However, no bibliometric investigation has been reported to guide the researchers and potential readers. METHODS Papers were collected from database Sci-expanded and Pubmed until May 22, 2008. The highly-producti...
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In Model Driven Engineering (MDE) model-to-model transformations are a key means for developing software systems. Manual manipulation of models can become unmanageable and expertise in model manipulation would need to be put in practice again and again. This technique has the potential to save a considerable amount of work from developers, as well as to avoid errors associated with manual proce...
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Natalizumab-treated patients have a higher risk of developing progressive multifocal leukoencephalopathy. Exposure to John Cunningham virus (JCV) is a prerequisite for PML (progressive multifocal leukoencephalopathy). To assess JCV exposure in multiple sclerosis patients, we performed a serological examination, obtained the antibody index, performed real-time polymerase chain reaction (PCR) to ...
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ژورنال
عنوان ژورنال: Virology Journal
سال: 2018
ISSN: 1743-422X
DOI: 10.1186/s12985-018-0939-1